He scored his 98th goal in the 59th minute to leave behind Teddy Sheringham's previous club record of 97 strikes.
According to BBC, Christian Eriksen smashed in a fourth from the edge of the penalty area late on after a fine backheel from Dele Alli.
While many find this speculation reasonable, Tottenham chairman Daniel Levy has dismissed the possibility of the move by suggesting that the 24-year-old will definitely stay with the Lilywhites for the new season.
Kane would go on to break that record 12 minutes later when he scored his second goal of the evening.
"I never see this type of mistake in the Premier League before", said Southampton manager Mauricio Pellegrino.
He continued: "There are a lot of numbers, but he can do everything because of his mentality and how he is - he is so professional".
But he says the loyalty of Kane, who has 125 Spurs goals in all competitions, makes him different to most modern players.
'I think it's really out of order that you relinquish that responsibility just cos you've gone 2-0 down one minute into the second half... there's still another 44 minutes plus injury time to play, and play your way back into the game like you did in the first half'.
Tottenham, who are now unbeaten in six matches, remain fifth in the Premier League, but are level on points with Liverpool and 18 points behind leaders Manchester City.
"It's so important to be there, fighting very close", Pochettino added. "I should have got back to being a bit more boring and a bit less adventurous". Obviously, it's something I have to address now.
Spurs fans were pleased with the performance their side put in and took to social media to provide their reaction to one of their attacking players. 'Hopefully his ability and goalscoring ability will help us along the way, but we've got to get back to the basics defensively like I did when I first started'. I saw some of the good sides of the players last week and I saw some of their worst sides in the second half today, which is massively worrying in terms.
He mentioned that members of the Dawa Party are free to support his State of Law Coalition or Abadi's Victory for Iraq Alliance. The alliance would aim to unify the country after a recent victory over "Islamic State" (IS) militants.
Military vehicles arrive to assist evacuation operations at an area damaged by mudslides in Montecito, Calif. on January 9. An evacuation order was issued recently near the burnt-down areas of Santa Barbara, Ventura and Los Angeles counties.
"As long as we can stay within the mid 90s, as far our graduation rate is concerned, I'm going to be pretty excited about it". IN requires students to pass state tests to graduate unless they can get a waiver by meeting other criteria.
The 29-year-old said his team settled for Parker because negotiations with WBC champion, Deontay Wilder , have proved too hard . He's consistently fought fighters in the world's top 10 and he's beaten them all easily.
Emergency personnel evacuate local residents and their dogs through floodwaters January 9 after a mudslide in Montecito , Calif. His father, Pinit Sutthithepa, and 2-year-old sister, Lydia, are among the missing, the county sheriff's office said.
This is despite the team trying to keep their relationship with the outspoken parent respectful as recently as last month. The Lakers ended their nine-game skid by defeating Atlanta 132-113. "So, it definitely felt good tonight".
Images posted on social media and used by Lebanese TV show a mangled vehicle , a large fire and black smoke rising above the city. Sidon Mayor Mohammed Saudi told Al-Manar TV that one person was wounded in the explosion as he opened the auto door.
However, they found themselves having to contain Kane , Son , Dele Alli and Christian Eriksen as Spurs' attacking four shone. Kane also became Spurs' all-time leading scorer in the Premier League , with his brace taking up to 98 league goals.
Overcoming a 20-0 run is rarely a recipe for success , but the Indiana Pacers had the right chefs in the kitchen on Friday night. The Cavaliers have dropped six of eight dating to a Christmas Day loss at defending champions the Golden State Warriors .
After the match, the 48-year-old said his players were exhausted after Wednesday's 0-0 draw with Arsenal in the Carabao Cup. The top-class goalkeeper has looked set to extend his contract in west London.
EPS Predictions Review: Tetra Tech, Inc. (TTEK)
The stock's 50-day average volume has been 1,228,184 shares, with an average of 25% of medium term indicators pointing toward Buy. A number of other hedge funds and other institutional investors have also added to or reduced their stakes in the business.
Ant McPartlin announces divorce from wife Lisa
Ant's romance has been the talk of tabloids over the past few months ever since he entered rehab for an addiction to painkillers. And his health was reportedly a factor in Ant's decision to divorce Lisa, whom he has been with for 23 years and married in 2006.
Centurion Test: South Africa all out for 335
To repeat what I started with - I surely think this team is capable of making a comeback in the series. Ashwin got one to hold its line just enough after pitching to take the edge of Markram's bat.
Chelsea make unwanted history with third straight 0-0 draw
The Portuguese responded by alluding to Conte's hair transplant: "I'm not going to lose my hair to speak about Antonio Conte ". It was Alan Pardew's first league victory since he took over as manager nine matches ago at the start of December.
White House doctor declares Trump 'in excellent health'
Trump's derogatory remarks cited by the Washington Post and New York Times were in reference to African countries and Haiti. Ghana is widely seen as a stable, peaceful country in an often turbulent region, and has close ties to the United States.
Trump says U.S. court system 'broken and unfair'
Richard Durbin of IL - a leader of the bipartisan Senate group - was among the seven lawmakers at the noontime meeting. Alongside it was a document outlining a "vision" for Trump's border wall: 700 miles, at a cost of $18 billion.