Too much Ibuprofen linked to male infertility

Ibuprofen male infertility issue joins cardiac risk as painkiller concerns grow

If you are concerned about your levels of testosterone and your ibuprofen use, though, it's worth chatting to your GP so you can get checked out and find a way to deal with chronic aches and pains in a healthy way.

During the last few decades, many other similar painkillers have been associated with health risks such as Acetaminophen, which is a common household drug for the American population. You should never mix ibuprofen with alcohol or take more than the prescribed amount in a 24 hour period.

Of course, it wouldn't be such a tragedy if people would take ibuprofen only on doctor's orders.

According to Bernard Jégou, co-author and director of the Institute of Research in Environmental and Occupational Health in France, the new study is a continuation of research that began with pregnant women. So, the researchers, based in Denmark and France, chose to test how the medication would impact male adults. So, to truly understand the matter, Jégou's team thought of an extensive study.

Though the exact reasons for the decline are not yet known; in a recent study, researchers have linked male infertility to Ibuprofen - a common painkiller. Men were then divided - 14 in an ibuprofen group, 17 in a placebo group - and the ibuprofen participants given 600 mg twice a day, or the equivalent of three tablets. Tests showed their testosterone levels hadn't changed, although the testes weren't producing adequate levels. A study of 31 men found that continued use of high dosages affected luteinizing hormone and the production of testosterone.

The best way to address a low testosterone level is with artificial hormones.

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Those who took the ibuprofen were more likely to have indications of testicular problems - including a condition called compensated hypogonadism that affects reproductive health - meaning men are less likely to be able to father a child.

Next was the "ex vivo" (outside the living body) component of the study.

The study also investigated several other hormones produced by the testes that were found to be reduced by ibuprofen.

The authors concluded that "we report a univocal depression of important aspects of testicular function, including testosterone production, after use of over-the-counter ibuprofen". But, don't worry, if you just want to boring the pain of a minor ankle sprain for a week or two, Jégou says, "it is sure that these effects are reversible".

But long-distance runners and athletes who regularly take ibuprofen during training or sports matches in order to ward off inflammation may want to keep an eye on the research.


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