Celta Vigo thrashed Sevilla 4-0 in their last home game, but this has been something of an inconsistent campaign for the Galician side, now in ninth place with 43 points.
"Resting Messi is a possibility like any other, but I think he is playing well, the other day he played a good game", Valverde said during a press conference on Monday.
"We are in an important week and we are coming off the back of a game three days ago, and we have the cup final".
Lionel Messi and Luis Suarez will continue to be the devastating duo upfront for Barcelona as the Catalans seek to take one step closer to the La Liga title, a necessity now that they are out of the Champions League, after the humiliating second-leg collapse against AS Roma.
In defence, Thomas Vermaelen looks likely to come in to give Gerard Pique a rest, while Nelson Semedo is set to start ahead of Sergi Roberto at right back.
Celta Vigo, meanwhile, sits in ninth place on the league table with 43 points from 32 matches.
"We have faced Celta three times already and it will be a tough game", said Valverde, whose side are looking to extend their LaLiga record unbeaten run of 39 games. That, of course, will be a tall order for the home team, as nobody has beaten them yet this season. In its last match against Barcelona, though, Celta Vigo fell 5-0.
As such, Celta head coach Juan Carlos Unzue wants all three points against the Catalan giants in midweek.
Barca's last loss in LaLiga came at Malaga on April 8 a year ago.
"We can not set out to draw the match, we must go for the win", Unzue is cited as saying by ABC International. "We have to go out and win, to stand up", Unzue told the press. "Playing against a big team is always an extra motivation for the rest, even if that is subconscious".
Unzue does not believe the Copa del Rey final will affect Barca's attitude.
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