Successfully bioengineered pig lungs may revolutionize organ transplants

Surgical team at UTMB during pig lung transplant

The team noticed the pigs' bodies didn't reject the new lungs, despite not using immunosuppressants to help keep rejection rates low - a technique that's common in transplants. "Somewhere down the line someday", says Nichols in a press announcement, "we may be able to take cells from somebody, maybe it's their stem cells, and produce an organ that is their organ, tissue-matched to them with no immune suppression needed that would function the way their own lung originally did".

The researchers hope that the technology could one day be used for human lung transplants.

"The number of people who have developed severe lung injuries has increased worldwide, while the number of available transplantable organs have decreased", study author Joaquin Cortiella, a professor of pediatric anesthesia, said in a university news release. A support scaffold was created using a lung from an unrelated animal that was treated using a special mixture of sugar and detergent to eliminate all cells and blood in the lung, leaving only the scaffolding proteins or skeleton of the lung behind. Already two weeks after transplantation, the laboratory lung had created the necessary blood vessel network that allowed it to survive in the body, which prevented the risk of pulmonary edema.

The team harvested lungs from dead pigs to construct a scaffold for the bioengineered lung to hold fast to.

Russia appoints Hollywood star Steven Seagal as 'goodwill ambassador' to US
He will receive no salary, the Ministry said, adding, "It's a case of people's diplomacy intersecting with traditional diplomacy". For more than a decade Seagal, who according to his own website is 66, has been a regular visitor to Russian Federation .

Scientists in the U.S. first created a "scaffold" which came from an unrelated donor pig, achieving this using a process in which all cells and blood are removed from the organ, leaving just a skeleton. The work, which was recently detailed in a study published by Science Translational Medicine, details the work and progress made over the last few years, reaching the point where no complication resulted from the transplants. Blood vessels and lung tissue cells were "repopulated", according to Science News.

The study was meant to assess how well the bioengineered lungs adapted and continued to mature within a large, living body.

The researchers assessed the development of lung tissue and integration of the bioengineered lungs at 10 hours, two weeks, one month and two months after the transplants. But they next want to study the long-term viability of the organs. However, it looks like the road is still long before human bioengineered lung transplants could take place.

The researchers said that with enough funding, they could grow lungs to transplant into people in compassionate use circumstances within five to 10 years. Because of this, many scientists have tried to create bioengineered lungs, although without notable success until now.


  • U.S. court orders Trump administration to fully reinstate DACA program

    U.S. court orders Trump administration to fully reinstate DACA program

    They shut down the government, but backed off when public opinion began to swing against them. The court says that if DHS wishes to end the program, it must give a rational explanation .
    Trade war costs China its stock market ranking

    Trade war costs China its stock market ranking

    In China's spot foreign exchange market, the yuan is allowed to rise or fall by 2% from the central parity rate each trading day. More than 2,400 stocks fell on the two bourses, with combined turnover at 284.8 billion yuan (about 41.4 billion USA dollars).
    Trump tweets insult at LeBron James

    Trump tweets insult at LeBron James

    Their history includes trading barbs when Trump revoked an invitation to the White House for the Warriors. Lemon asked James what he would say to Trump if he were sitting in the room.
  • Donald Trump insults LeBron James' intelligence: 'I like Mike'

    Donald Trump insults LeBron James' intelligence: 'I like Mike'

    After throwing insults at both men, Trump also mentioned that he likes "Mike", which is nearly certainly a reference to Jordan. James spoke to Lemon from the public, non-charter school he opened for at-risk kids in Akron, called the I Promise school.
    Cristiano Ronaldo in apparent social media snub to Real Madrid

    Cristiano Ronaldo in apparent social media snub to Real Madrid

    And Ramos' preferential treatment is reportedly not going down well with his fellow colleagues per Spanish outlet Marca . Spanish contingent Isco, Marco Asensio , Lucas Vasquez and Nacho came back on July 25th following their Russian venture.
    Seoul's temperature rises to record 39.4 C

    Seoul's temperature rises to record 39.4 C

    The temperature in South Korea hit a record high yesterday amid a scorching mid-summer heatwave, the weather services agency said. The temperature reached 40.4 degrees in the southeastern province of North Gyeongsang, and 39.6 degrees in the capital Seoul.
  • Five things we learned from the 1st England-India Test

    Five things we learned from the 1st England-India Test

    Stokes is the kind of cricketer all captains want in their side - someone with the ability to make things happen with bat or ball. But the sight of Kohli walking purposefully from the middle with Dinesh Karthik and a job half done was not what England wanted.
    Foodora to cease Australian operations

    Foodora to cease Australian operations

    That case is shaping up as a major test case for all so-called "gig economy" employers, including rivals Deliveroo and UberEats. Food delivery giant Foodora has today confirmed it is exiting the country, in order to concentrate on markets overseas.
    Manchester City chase visa for Douglas Luiz amid transfer frustration

    Manchester City chase visa for Douglas Luiz amid transfer frustration

    The team needed cover after Yaya Toure left and Pep said, of Douglas: "I think he has the potential to play with us". Luiz was a key figure as Chelsea won the 2016-17 Premier League title in Antonio Conte's first season as head coach.
  • Alps plane crash: 20 feared dead after sightseeing flight smashes into mountain

    Alps plane crash: 20 feared dead after sightseeing flight smashes into mountain

    Police said a large rescue mission had been deployed to the scene of the crash, including five helicopters. The plane crashed in an inaccessible area of forest in the Rengg mountain pass in the canton of Nidwalden.
    Chinese dissident in his 80s arrested at home during live TV interview

    Chinese dissident in his 80s arrested at home during live TV interview

    Sun asks the security officials: "Did I say anything wrong?" before going on to explain his criticisms of government policy. In an interview with the South China Morning Post, Sun said , "If my rights are infringed then I have to fight back".
    Alderweireld tells Spurs: Let me join Man Utd!

    Alderweireld tells Spurs: Let me join Man Utd!

    Alderweireld has entered the final 12 months of his contract but Tottenham are demanding in excess of £60m for his signature.


Latest news

China's Huawei eyes smartphone summit after passing Apple
Huawei was able to realize 54 million smartphones , while Apple sold only 41.3 million iPhone. In 2017 Huawei shipped 153 million smartphones which were 10% more than 2018.

Man United reportedly move for €55m Bayern defender
German newspaper BILD report United are looking to swap Martial for Bayern centre-back Jerome Boateng . Alexis Sanchez and Marcus Rashford travelled with Manchester United's squad to Germany.

New Mandatory Evacuation Ordered In Lake County
The fire burned slowly for days before winds suddenly whipped it up last week and drove it furiously through brush and timber. Workers who live in Yosemite's popular Valley region were ordered to leave on Friday because of inaccessible roads.

Keys joins San Jose exodus — WTA roundup
I can't help how I am", the third-seeded Williams said when asked if she would continue with the new on-court demeanor. Open where she lost to fellow American Sloane Stephens, is ranked 12 in the world and was the second seed in San Jose.

Police called on black student eating lunch at Smith College
The woman who has identified herself as the student posted on Facebook that it was outrageous she couldn't eat her lunch in peace. Hunter also said she has reached out to Kanoute to "offer support and discuss next steps" following the incident.

Rafa Benitez still seeking added competition for Newcastle squad
Rafael Benitez is one of the most likable men in football. "Shut up Rafa - or walk - which is your right", he wrote. Sam Allardyce also gave his opinion on the situation at his former club earlier today.

Travis Scott Drops 3 Unreleased Tracks on .WAV RADIO
Me and Lachappelle set out tooo (sic) create images that i grew up watching him create for years that inspire me today. Later, Travis Scott posted that same cover to his own Instagram, but with Lepore and only Lepore removed.

How do Druze Israelis view the 'nation-state' law?
The same way we fight for the existence of the state, we are determined to fight for the right to live in equality and dignity. The Druze, a religious sect spread throughout Israel, Lebanon and Syria, make up a subset of Israel's Arab population.

Jerry Rice says he'd definitely take Terrell Owens over Randy Moss
I have made a lot of mistakes, but that's what happens when you start a professional football career at 22 years old. If you had the chills after Randy Moss's Hall of Fame speech on Saturday night, well, you're not the only one.

Wow! Did Meghan wear a daring lace bra to the wedding?
Harry and Charlie have been close ever since they attended Ludgrove Prep School in Berkshire together. Since becoming the Duchess of Sussex, Meghan Markle has worn a slew of expensive designer outfits.

The Stakes: TJ Dillashaw vs. Cody Garbrandt II
Between rounds, Cejudo's corner urged their fighter to draw on his Olympic Gold wrestling experience and take Johnson down. At UFC 217, Dillashaw was knocked down late in the first round and might have only been saved by the bell.

Imran Khan summoned by Pakistan's anti-graft body on Aug 7
PTI has said it expects Khan to take the oath as prime minister before August 14, Pakistan's independence day. He was earlier summoned on July 18, but he failed to appear before the panel, citing elections.

Child dies after being thrown into river by mother
The investigation was closed Tuesday after no evidence of maltreatment, abuse or neglect was found, the agency said. A girl died Thursday afternoon after being thrown into the Hillsborough River, according to Tampa police.

15 killed as explosions rock mosque in Afghanistan
Afghan residents walk inside a damaged mosque after a suicide attack during Friday prayers in Gardez of Paktia province. The attack comes as urban areas across Afghanistan have been rocked by an increasing number of attacks.

Iran preparing major military exercise, USA officials say
Early this week, Trump said at a news conference, answering a reporter's question, that he would meet Iran "anytime they want". He also said that Iran could block one of the most important oil artery of the world, passing through the Strait of Hormuz.

Other news