Novartis AG agreed to buy United States drugmaker Endocyte Inc. for $2.1 billion, snapping up a potential blockbuster therapy for prostate cancer and helping to fill out a treatment area targeted by the Swiss pharmaceutical giant.
Since taking over in February, Narasimhan has shed over-the-counter medicines and generic pills while pushing a spinoff of Novartis's Alcon eyecare unit come 2019. The company previous year agreed to buy Advanced Accelerator Applications SA for about $3.9 billion, getting a radiopharmaceutical company whose drugs are used to diagnose and treat diseases such as cancer.
Endocyte is also developing a preclinical adaptor-controlled CAR-T therapy, which is created to overcome traditional CAR-Ts' reliance on the activity and specificity of T cells engineered to recognize specific, naturally expressed targets.
News of the latest bolt-on deal came as Novartis revealed a 6% rise in third-quarter sales to $12.8bn in constant currencies on the back of gains for new psoriasis drug Cosentyx (secukinumab) and Entresto (sacubitril/valsartan) for heart failure - up 37% to $750m and 113% to $271m, respectively - as well as Sandoz' biosimilar drugs.
But analysts said investors were keener on Narasimhan's progress in recasting the broad European healthcare giant that former Chairman Daniel Vasella envisioned before his 2013 exit into a focused, data-driven drug maker.
This offer represents a premium of 54% percent to Endocyte's closing price of $15.56 on October 17, 2018.
Narasimhan said that transaction prompted Novartis to expand relationships with USA and European nuclear medicine centers. "With Endocyte, we saw a great fit". S., makes radioactive drugs coupled with molecules that target specific cells to deliver treatments to tumors.
Heading up Endocyte's pipeline is Lu-PSMA-617, a potential first-in-class drug for the treatment of metastatic castration-resistant prostate cancer (CRPC).
Hazard is the Premier League's top scorer this season with seven goals to his name, two more than the next four on the list. Following the 0-0 draw, Mourinho blamed the Greater Manchester Police for refusing to provide an escort for the team bus.
Los Angeles starter Rich Hill went five innings, giving up one run on three hits with three walks and six strikeouts. The Dodgers' bats didn't get going until the fifth, one day after they had a grind out a 2-1, 13-inning victory.
In August, Southeast Asian nations and China adopted a negotiating framework for a broader code of conduct in the South China Sea. But she added its significance should not be overstated as it was a one-off drill in waters that were not disputed.
He was also prohibited from any receiving guest beside his team of lawyers, a move which effectively cut him off from the world. Ecuador granted him asylum in August 2012, saying it feared his human rights might be violated if he was extradited.
President Donald Trump threatened on Thursday to close the U.S. -Mexico border if Mexico does not stop the migrants. And requests for asylum will be reviewed on a case-by-case basis, a process that can take up to four months.
The southern states of the USA , as well as those in the Mid-Atlantic, are expected to receive above-normal precipitation. For those looking for snowfall projections, you won't find those in NOAA's winter outlook .
The 59-year-old former banker accepts Mourinho is, for the time being, a better coach than him - and can win trophies again. Cristiano Ronaldo, likewise, when Juventus visit Old Trafford in the Champions League three days later.
In FP1 I only did a few laps because we need the tires to last until FP3 and there's very little to learn in the rain". Following the sodden second practice, Vettel told reporters he did slow down for the red flags.
The " Me Too " movement gained momentum in India after Dutta came forward and took a stand against Nata Patekar. Tanushree has also filed a police complaint against Nana and others who she feels were involved in the action.
Prince Harry opens extended Anzac Memorial in Hyde Park
Despite the overcast weather, large crowds descended on the golden sands to catch a glimpse of Harry and Meghan in the flesh. Olivia Rose's mother Louisa, 38, said: "He said thank you very much for the present for the baby".
SARKAR Teaser : Vijay’s show all the way
After the blockbuster movies- Thuppakki and Kaththi , this is the third time, Vijay and A R Murugadoss have teamed up for Sarkar . It looks like Varalaxmi Sarathkumar and Radha Ravi are playing ruthless politicians in this upcoming political drama Sarkar .
Antarctic Ice Shelf "Sings" as Winds Whip Across Its Surface
The snow provides a barrier between the air and the ice, which insulates it from warming temperatures, comparing it to a fur coat. This seismological monitoring can be used to observe the ice shelves from remote locations, according to the study.
Cleveland Browns trade RB Carlos Hyde to Jacksonville Jaguars
According to ESPN's Adam Schefter, the Cleveland Browns have traded running back Carlos Hyde to the Jacksonville Jaguars . Update: per Tom Pelissero and Sirius XM NFL Radio, the Browns will receive a fifth-round pick in 2019 from Jacksonville.
Royal tour: Harry and Meghan brighten up Bondi Beach
Meghan has always been a huge advocate for yoga, so it's not surprising that she's filling her time with some physical activity. Charlotte Connell, who is 23 weeks pregnant , was at the beach with her son Finn.