Appendix removal is linked to lower risk of Parkinson's

Parkinson's-inducing protein in the gut points to possible link between gastrointestinal tract and disease

However, the search for the origins of Parkinson's still has not made it clear why the disease develops in some people but not others.

Parkinson's disease is an incurable brain disease that affects the senses, memory and mood. And the appendix, an organ whose usefulness remains in doubt, also proved to be a reservoir of the substances that kill brain cells. People who have surgery removal of appendicitis (the appendix has inflammation) have a reduced risk of developing Parkinson's by 19% to 25%, provided that the intervention is done early in life, several years before the onset of the first symptoms of the disease.

This might be why people who have their appendix removed early in life have a decreased risk of developing Parkinson's. But researchers say it is a storage site for gut bacteria, is linked to immune response, and appears to be a gathering place for a key protein implicated in Parkinson's, known as alpha-synuclein. "That's what we plan to look at next - which factor or factors tip the scale in favor of Parkinson's".

The study showed that nearly everyone in this study had alpha-synuclein protein present in their appendix.

Up, Up & Away in a Beautiful Balloon in Fortnite's Latest Update
This is a decision that has already divided the community but there are plans to change and improve the feature in the future. Epic has also announced changes are coming to the Glider Re-Deployment system after its initial testing.

The researchers unexpectedly discovered the abnormal form of the α-synuclein protein, not only in the appendixes of Parkinson's patients, but also in healthy individuals.

University of Pennsylvania neuroscience and geriatric medicine professor John Trojanowski, who was not involved in the study, thought it was excellently done and agreed with the paper's statement that the appendix is a source of mis-folded alpha-synuclein that could be targeted for therapeutic strategies. For those living in rural areas it was even more advantageous, as there was a 25-percent reduction in disease risk, the reveals.

Viviane Labrie, an assistant professor at Van Andel Research Institute in MI and senior author of the study, said: "Despite having a reputation as largely unnecessary, the appendix actually plays a major part in our immune systems, in regulating the makeup of our gut bacteria and now, as shown by our work, in Parkinson's disease".


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