Boris Johnson, a leading supporter of Brexit who quit as foreign secretary in July, praised his brother's decision, saying they were "united in dismay" - despite their opposing views on Brexit - over May's handling of the negotiations.
The Conservative MP added that it would be a "democratic travesty" if the public did not get to have their say once again.
"It is entirely right to go back to the people and ask them to confirm their decision to leave the European Union and if they choose to do that, to give them the final say on whether we leave with the prime minister's deal or without it", he added.
"It has become increasingly clear to me that the withdrawal agreement, which is being finalised... will be a bad mistake", he wrote in a stinging resignation statement.
The UK is set to divorce the European Union on 29 March 2019, with the transition period set to end in December 2020, and Downing Street is seeking to settle the remaining five percent of the withdrawal agreement to prompt a deal-making summit later in November.
A Cabinet minister said leader of the pro-Brexit European Reform Group Jacob Rees-Mogg also supports the plan, while other Brexiteers said it could be worth exploring in more detail.
Mr Johnson said his role as transport minister had caused him concern about the impact of a no-deal outcome.
His resignation follows controversy on Thursday after Brexit Minister Dominic Raab faced ridicule over admitting that he "hadn't quite understood" how dependent the United Kingdom was on the Dover-Calais crossing for its trade.
Timberwolves trade Jimmy Butler to Sixers
His rookie season was the lockout-shortened 66-game season when he only played 42 games, but his second season he played all 82. He requested a trade in September and has been eagerly awaiting a deal while the Timberwolves tried to find a trade partner.
Labour Shadow Brexit Minister Jenny Chapman said that Theresa May had "lost all authority and is incapable of negotiating a Brexit deal within her own party, let alone with the EU".
"This would not be about re-running the 2016 referendum, but about asking people whether they want to go ahead with Brexit now that we know the deal that is actually available to us". My loyalty to the party is undimmed.
The departing minister noted Brexit had divided Britain, political parties and "families too", but added: "what is now being proposed won't be anything like what was promised two years ago" during the referendum campaign.
A spokesperson for May's office said later Friday that under no circumstances would a second referendum be held.
Johnson is the 14th minister to have resigned from government since November previous year.
"My brother Boris, who led the leave campaign, is as unhappy with the Government's proposals as I am".
Johnson said this morning that other ministers are thinking hard about the Brexit and its implications.
Former BBC journalist and current University of Kent chancellor Gavin Esler said: "This - from a hugely respected minister - is an important development".
On Tuesday (6 November) Ofgem announced the price cap will be set at £1,137, which is just £1 higher than the proposed amount. Consumers in Northern Ireland have a separate energy regulator and already have a price cap.
Utah's official Twitter account seemed more excited to welcome the former franchise face back than their fans did. Utah opened the third quarter on a 17-6 run. "We just didn't have a presence out there, so they played freely".
In Fairbanks , Sears Holding announced 40 stores would be closing, including the location on Airport Way in Fairbanks . Liquidation sales at the 40 additional closures, including in Grand Island are set to begin late next week.
The group screamed different explicit and derogatory phrases during their violent protest outside of the Fox News host's house. Ted Cruz (R-Texas) at a Washington restaurant in September, forcing Cruz and his wife to leave the establishment.
Prior to the arrest, the registered Republican was living in a van plastered with pro-Trump and anti-Democrat stickers. The document said he mailed 16 improvised explosive devices though the US mail to victims across the country.
The survey also showed that 15-year FRM this week averaged 4.33 percent, while the reading was 3.24 percent a year ago. Freddie Mac makes home possible for millions of families and individuals by providing mortgage capital to lenders.
On Saturday, Petain will be honored alongside seven other French generals at a ceremony to be held at Les Invalides in Paris. France's leading Jewish organization, known by the initials CRIF, issued a searing criticism of Macron's stance.
He's tough so he gets up and he plays. "Guys like that, the only thing you can do is stuff them up by coaching them". He takes the ball to the line, he puts his body on the line, he doesn't play in a dinner suit.
Those that suffer from Celiac disease may be able to start eating gluten again thanks to an experimental vaccine. About 80 to 90 percent of those who have celiac disease also carry the immune recognition gene.
A leaked letter from the Prime Minister to Mrs Foster and her deputy Nigel Dodds set out Mrs May's approach. Mrs May says in the letter that the European Union is still pushing for a "backstop to the backstop".
Scotiabank Initiates Coverage on Canopy Growth (CGC)
If the stock volatility is on the rise in the market, then it will create more risky situation of the security and vice versa. On The Other side Starbucks Corporation a U.S. based Company, belongs to Services sector and Specialty Eateries industry.
Kuchar sinks eight birdies to take the lead in Mexico
Park Sung Hyun shot a 67 and fellow South Korean Kim Sei Young had a 68 to put them both within five strokes of the lead. He was leading by one shot when his tee shot sailed right and landed in bushes near rocks.
Fallout 76 Update Lands -36GB Patch
We've seen too many games coming to an untimely death and games that just keep breathing even after their glory days. Stability: The Fallout 76 game client and servers have received significant stability improvements.
76ers pull away late as Pacers lose 100-94
Redick scored 10 points, his 21st consecutive double-figure game dating to March 26, 2018. IN is now 5-2 against the Eastern Conference and 3-1 against Atlantic Division opponents.
Midterm lessons: five key takeaways from the election results
The 78-year-old Pelosi was the first woman to be House speaker, from 2007 to 2011, when Democrats last held a House majority. As the returns came in, voters were on track to send at least 99 women to the House, shattering the record of 84 now.
Malkin avoids suspension for Oshie hit
But in hockey, there is occasionally a gulf between what you deserve and what you get. "You want to be in there and try to help". Oshie proved it once more when he curled around the left faceoff circle, saw an opening and darted toward the front of the net.
Could the oil Industry in India See Higher Profits?
One of the issues for Indian oil companies is their requirement to sell below market to subsidize prices in their home country. The US pulled out of the agreement earlier this year as President Trump claimed he was looking for a better deal.